Students may choose from courses in English, math, social studies, science, world languages, fine arts, health and physical education, computer technology, and applied arts, which includes business education and consumer and family studies. A variety of interdisciplinary courses and Advanced Placement (AP) courses are also offered. Students must earn 26.4 credits to graduate. (A "*" indicates required courses). In addition to the regular curriculum, students must complete 50 hours of community service, 3 half-day shadowing experiences, 50 hours of internship, a portfolio, and a senior project.

University High School students also have the option of earning a diploma after following a graduation pathway. Some pathways place an emphasis on an area of strong interest, passion, or talent. The goal of a pathway is to develop and graduate young people who are ready for real world experiences - a four-year college, two-year associate degree programs, skilled trade apprenticeships, or jobs in the global, technological workplace. Students may elect to enter a pathway program after their freshmen or sophomore year.